DSIP Dosing Guide

What It's Used For

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide that promotes deep, restorative sleep and regulates neuroendocrine functions. It works by modulating sleep-wake cycles and supporting the body's natural stress response systems.

  1. Sleep Optimization:
    • Improves sleep quality and duration
    • Increases deep delta wave sleep (Stage 3-4)
    • Reduces sleep onset time (falling asleep faster)
  2. Stress and Anxiety Management:
    • Lowers cortisol levels
    • Modulates hypothalamic-pituitary-adrenal (HPA) axis
    • Promotes relaxation and reduces anxiety
  3. Pain Management:
    • Reduces pain perception through opioid receptor interaction
    • Helps with chronic pain conditions
    • Alleviates headaches and migraines
  4. Withdrawal Support:
    • Assists with substance withdrawal symptoms
    • Particularly effective for opioid and alcohol withdrawal
    • Reduces withdrawal-related insomnia and discomfort

How Much to Take

  1. Dose:
    • Standard: 100-300 mcg per dose
    • Clinical dose: 25 nmol/kg (approximately 21.4 mcg/kg body weight)
    • Beginners: Start with 50-100 mcg
  2. How Often:
    • Once daily in the evening
    • Some protocols use 1-3 times weekly
  3. When to Take:
    • 1-3 hours before bedtime for optimal results
    • Can be taken earlier in evening for gradual onset
    • Not a sedative - doesn't require immediate bedtime administration

How Long to Use It

  • Initial Trial: Use for 7-14 days to assess effectiveness
  • Cycle Length: Can be used for 4-8 weeks continuously
  • Break Period: Take 2-4 weeks off between cycles
  • Maintenance: Some use 1-2 times weekly long-term

Need-to-Know Information

  1. How It Works:
    • Promotes natural sleep rather than sedation
    • Increases delta wave activity during deep sleep
    • Crosses blood-brain barrier easily
    • Works rapidly (onset within 10-30 minutes)
    • Short half-life (15-30 minutes) but lasting effects
  2. Key Benefits:
    • Sleep Quality: Increases deep sleep by 59-70%
    • Stress Reduction: Normalizes cortisol rhythms
    • Neuroprotection: Reduces oxidative stress in brain
    • Hormone Balance: Increases LH and GH while decreasing somatostatin
    • No Dependency: Non-sedative, non-habit forming
  3. Who Should Avoid It:
    • Pregnant or breastfeeding women
    • Children under 18 (unless prescribed)
    • Those with severe psychiatric conditions
    • Individuals with undiagnosed neurological disorders
  4. Possible Side Effects:
    • Generally very well-tolerated with minimal side effects
    • Mild drowsiness or grogginess (if dose too high)
    • Slight headache (rare)
    • Temporary mood changes (very rare)
    • No sedation in classic pharmacologic sense

How to Mix and Store It

  1. Mixing Instructions:
    • Use bacteriostatic water for reconstitution
    • Example: Add 2 mL of bacteriostatic water to a 2 mg vial
    • This creates 1000 mcg/mL concentration
    • For 100 mcg dose, draw 0.1 mL (10 units on insulin syringe)
    • For 250 mcg dose, draw 0.25 mL (25 units)
  2. Storage:
    • Store reconstituted vials in refrigerator (2-8°C)
    • Use within 30 days after mixing
    • Keep unmixed vials in cool, dry place
    • Protect from light and heat

How to Inject

  1. Injection Method:
    • Subcutaneous injection (under the skin)
    • Where to Inject: Fatty areas like stomach, thigh, or upper arm
    • Alternative: Some use intranasal administration (nasal spray)
  2. Injection Tips:
    • Clean injection site with alcohol swab
    • Pinch skin and insert needle at 45-degree angle
    • Inject slowly and steadily
    • Rotate injection sites to prevent irritation

Example Dosing Schedule

Week 1-2 (Assessment Phase):

  • Day 1-3: 50 mcg, 2 hours before bed
  • Day 4-7: 100 mcg, 2 hours before bed
  • Week 2: 100-200 mcg, 1-2 hours before bed

Maintenance Protocol:

  • Option A: 200-250 mcg nightly for 4 weeks
  • Option B: 300 mcg every other night
  • Option C: 250 mcg 2-3 times weekly

For Withdrawal Support:

  • Acute Phase: 250-300 mcg every 3-4 hours as needed
  • Maintenance: 200 mcg nightly for 7-14 days

Extra Tips for Best Results

  1. Optimize Sleep Environment:
    • Keep bedroom cool (65-68°F)
    • Complete darkness for best delta wave production
    • Minimize noise and disruptions
  2. Timing Strategies:
    • Experiment with timing (1-3 hours before bed)
    • Effects last 3-4 hours after injection
    • Can take earlier if you have trouble with sleep onset
  3. Stack Considerations:
    • Can combine with magnesium glycinate for enhanced relaxation
    • Avoid combining with other sleep medications initially
    • May enhance effects of melatonin
  4. Monitor Your Response:
    • Keep a sleep diary to track improvements
    • Note changes in sleep quality, not just duration
    • Pay attention to morning alertness and mood
  5. Lifestyle Support:
    • Maintain consistent sleep schedule
    • Avoid screens 1-2 hours before bed
    • Limit caffeine after 2 PM
  6. Special Considerations:
    • DSIP is a sleep modulator, not a sedative
    • Works best for disrupted sleep patterns
    • May increase daytime alertness and activity
    • Effects build up over multiple administrations