Dosing, Safety and Suggestions

What It's Used For

Adipotide is a synthetic peptide that targets fat cells by disrupting their blood supply, leading to targeted fat cell death. It works by binding to specific receptors (ANXA2 and prohibitin) found primarily on blood vessels supplying white adipose tissue.

  1. Weight Loss and Fat Reduction:
    • Reduces white adipose tissue by cutting off blood supply to fat cells
    • Promotes rapid weight loss through targeted fat cell apoptosis
  2. Metabolic Health:
    • Improves insulin sensitivity and glucose tolerance
    • Reduces insulin resistance markers
  3. Body Composition:
    • Decreases body mass index (BMI) and abdominal circumference
    • Targets visceral fat deposits linked to metabolic disorders
  4. Diabetes Management Support:
    • Shows potential for improving Type 2 diabetes markers
    • Enhances metabolic function through fat reduction

How Much to Take

  1. Dose: 0.01 mg per kg of body weight per day
    • For a 200 lb (90 kg) person: approximately 0.9 mg daily
    • For a 150 lb (68 kg) person: approximately 0.68 mg daily
  2. How Often:
    • Once daily subcutaneous injection
    • Consistent timing each day for optimal results
  3. When to Inject:
    • Inject at the same time each day (morning or evening)
    • Best administered on an empty stomach
    • Maintain consistent schedule throughout cycle

How Long to Use It

  • Cycle Length: Use for 28 days (4 weeks), followed by a break of 4-8 weeks
  • Protocol Variation: Some protocols suggest tapering doses in weeks 3-4
  • Repeat Cycles: Can be repeated after adequate break period if needed

Need-to-Know Information

  1. How It Works:
    • Binds to prohibitin and ANXA2 receptors on fat tissue blood vessels
    • Causes apoptosis (programmed death) of fat cells by cutting off blood supply
    • Specifically targets white adipose tissue while sparing brown fat
  2. Key Benefits:
    • Rapid Weight Loss: Studies show 11% body weight reduction in 28 days
    • Improved Insulin Sensitivity: Enhanced glucose metabolism
    • Targeted Fat Loss: Reduces visceral and subcutaneous fat
    • Metabolic Enhancement: Improved markers for Type 2 diabetes
  3. Who Should Avoid It:
    • Pregnant or breastfeeding individuals
    • Those with kidney disease or impaired kidney function
    • Individuals with cardiovascular conditions
    • Anyone with active cancer (consult doctor)
  4. Possible Side Effects:
    • Mild kidney function changes (usually reversible)
    • Nausea or decreased appetite
    • Injection site reactions
    • Dehydration risk
    • Temporary changes in electrolyte balance

How to Mix and Store It

  1. Mixing Instructions:
    • Use bacteriostatic water to reconstitute the peptide
    • Example: Add 2 mL of bacteriostatic water to a 10 mg vial
    • This creates a 5 mg/mL concentration
    • For a 0.9 mg dose, draw 0.18 mL into the syringe
  2. Storage:
    • Store mixed vials in the fridge at 2-8°C
    • Use within 28-30 days after reconstitution
    • Unmixed vials: Store in freezer at -20°C for long-term storage
    • Keep away from direct light

How to Inject

  1. Injection Method:
    • Where to Inject: Subcutaneous (under the skin) in fatty areas like stomach, thigh, or buttocks
    • Injection Tips:
      • Rotate injection sites daily to prevent irritation
      • Pinch skin fold and insert needle at 45-90 degree angle
      • Inject slowly and steadily
      • Clean injection site with alcohol swab before injecting

Example Dosing Schedule

Week 1-2:

  • Full dose based on body weight (0.01 mg/kg)
  • Morning injection before breakfast

Week 3-4:

  • Option to maintain full dose or taper to 0.5-0.75 of initial dose
  • Continue morning injection schedule

Post-Cycle:

  • 4-8 week break before considering another cycle

Extra Tips for Best Results

  1. Monitor Kidney Function:
    • Consider baseline kidney function tests before starting
    • Watch for signs of dehydration or electrolyte imbalance
    • Stay well-hydrated throughout the cycle
  2. Support Fat Loss:
    • Maintain a balanced, nutrient-rich diet
    • Include moderate exercise to enhance results
    • Focus on protein intake to preserve lean muscle
  3. Track Your Progress:
    • Take weekly body measurements and photos
    • Monitor weight changes and body composition
    • Keep a log of any side effects or changes
  4. Hydration is Key:
    • Drink plenty of water throughout the cycle
    • Monitor urine color as hydration indicator
    • Consider electrolyte supplementation if needed
  5. Start Conservative:
    • Consider starting with a lower dose for the first few days
    • Gradually increase to full dose if well-tolerated
    • Stop immediately if severe side effects occur
  6. Combine Wisely:
    • Can potentially be stacked with other peptides after research
    • Avoid combining with other experimental compounds initially
    • Consult with knowledgeable practitioners about combinations